The recent advancement in Next Generation Sequencing (NGS) technology gives rise to linking omics data such as genomics, proteomics and metabolomics with clinical data is referred to as clinico-genomic environment. This integrated clinico-genomic data is a basic building block for Precision Health and Personalized Medicine (PHPM). The scientists & clinicians are able to design the research experiments and choose patient cohorts not only based on clinical data but also based on omics data for designing most valuable personalized medicine. Achieving efficient personalized treatments is often hindered by the lack of integrated translational research informatics platforms.

SIDRA integrated Translational Research Informatics Platform (SIDRAiTrip) is a research and development project at SIDRA medical and research center. The objective of this project is to design, develop, implement, deploy and demonstrate a novel, comprehensive, feature-rich, and secure biomedical research platform. This SIDRAiTrip uses an effective “cohort selection” process from petabytes of genomic and clinical data, which necessitates the development of new types of translational research informatics platforms to allow physician, scientists and translational researchers to mine, analyze and visualize a variety of omics data in the context of defined clinical outcomes. This SIDRAiTrip platform uses 3-tier approach: a) data processing, b) data aggregation and c) user-interface layer.

The SIDRAiTrip utilizes the High Performance Computing (HPC) paradigm as the underlying computing infrastructure to address computing & memory-intensive genomic analysis and data-intensive clinical analytic type of operations. Furthermore, the SIDRAiTrip addresses the so-called ‘translational informatics’ concept, which is expediting the research studies/discoveries from bench, i.e. row genomics data produced by the NGS instruments, all the way to the clinical side, i.e. clinicians accessing the processed data out of the research translational platform. Hence, the SIDRAiTrip provides best hassle-free prediction and new approach to realize translational informatics that leads to precision health personalized medicine.